RG Tüscher

Head: Univ.-Prof. Dr. Oliver Tüscher
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Staff:
Dr. Yuranny Cabral-Calderin, postdoc
Anya Dietrich, PhD student
Dr. Bianca Kollmann, postdoc
Edoardo Pinzuti, PhD student
Michael Schaum, PhD student
Dr. Alexandra Sebastian, postdoc
Dr. Dr. Daniel Turner, assistant physician

Research overview:
Our group uses modern methods of cognitive behavioral research (behavioral tests and ambulatory assessments) and neurophysiology (fMRI, DTI / VBM, EEG / fMRI, EEG, MEG, EEG / MEG, PET, Imaging Genetics) to understand neurocognitive mechanisms of resilience of stress-related mental problems and disorders. Our main research goal and research topic is the systematic investigation of self-control as a resilience mechanism, in particular the cognitive domains emotion regulation (ER), impulse control (IC), attention (AC) and their interaction, as well as the translational mechanisms of stress vaccination, taking into account inter-individual differences and aging processes. Oscillatory mechanisms and differences of network excitability in relation to individual resilience are the focus of our neural resilience hypothesis.

Current research projects:

  • Mechanisms of emotional interference control
  • Mechanisms of proactive interference control
  • Transfer of cognitive training effects in cognitively healthy seniors: mechanisms and modulators
  • Translational mechanisms of stress vaccination as a resilience mechanism
  • Resilience-focused evaluation of data from the Gutenberg Brain Study (GBS)
  • Supervision of the satellite studies of the GBS
  • Carrying out the human PRG-1 studies
  • Resilience and political participation
  • Establishment of ecological-valid instantaneous evaluation and intervention technology (AA and EMA / EMI)
  • Support of the central, longitudinal resilience studies MARP and LORA
  • Development of innovative non-invasive brain stimulation methods and pharmacological interventions to promote resilience
  • Implementation of a long-term study to capture resilience and investigate resilience factors (MARF)

External collaboration partners:

  • Univ.-Prof. Dr. Michael Wibral, MEG Labor, Brain Imaging Center, Goethe University Frankfurt, Frankfurt/Main, Germany
  • Univ.-Prof. Dr. Henrik Walter, Department of Psychiatry and Psychotherapy, Humboldt University Berlin, Berlin, Germany
  • Univ.-Prof. Dr. Birte Forstmann, University of Amsterdam, Netherlands
  • Prof. Dr. David Silbersweig, Brigham & Woman‘s Hospital, Harvard Univ., Boston, USA

Funding:

  • German Research Foundation (DFG)
  • German Ministry of Education and Research
  • Ministry of Science of Rheinland Palatinate, Germany
  • Boehringer Ingelheim Foundation

Key publications:

  • Franke AG, Gränsmark P, Agricola A, Schühle K, Rommel T, Sebastian A, Balló HE, Gorbulev S, Gerdes C, Frank B, Ruckes C, Tüscher O, Lieb K (2017) Methylphenidate, modafinil, and caffeine for cognitive enhancement in chess: A double-blind, randomised controlled trial. Eur Neuropsychopharmacol 27(3):248-260.
  • Schmüser L, Sebastian A, Mobascher A, Lieb K, Feige B, Tüscher O (2016) Data-driven analysis of simultaneous EEG/fMRI reveals neurophysiological phenotypes of impulse control. Hum Brain Mapp 37(9):3114-36.
  • Sebastian A, Jung P, Neuhoff J, Wibral M, Fox PT, Lieb K, Fries P, Eickhoff SB, Tüscher O, Mobascher A (2016) Dissociable attentional and inhibitory networks of dorsal and ventral areas of the right inferior frontal cortex: a combined task-specific and coordinate-based meta-analytic fMRI study. Brain Struct Funct 221(3):1635-51.
  • Kalisch R, Müller MB, Tüscher O (2015) Advancing empirical resilience research. Behav Brain Sci. 38:e128.
  • Kalisch R, Müller MB, Tüscher O (2015) From descriptive to mechanistic research in the field of resilience: a conceptual and practical framework for neurobiological and translational studies. Behav Brain Sci 38:e92.