Ongoing Studies

Gutenberg Brain Study

The "Gutenberg Brain Study" (GBS) is a platform project of the Focus Program Translational Neuroscience (FTN). The GBS is intended to strengthen the translational activities of the FTN with respect to human research studies.

The GBS is a population-based cohort of subjects that have consented to provide basic psychological health and genetic (DNA) information, life history, personality and socio-demographic data purposefully designed to assess resilience to common life stress (in contrast to resilience following disaster, which has been the subject of most studies so far) and to test its relation to genetic determinants. Test subjects were genotyped according to socio-demographic parameters, environmental variables and, depending on the genotype or gene-environment combination, studied further in satellite projects with regard to brain structure and function.

The overall research theme of the GBS is the explanation of molecular aspects of brain structure and function. In addition to the study of the normal brain, mechanisms, in particular those that enable the human brain to respond to environmental influences (e.g. stress), that preserve function and structural integrity will be investigated.

Further information about the GBS can be found here.

The GBS is located in the Department of Neurology and is led by Dr. Oliver Tüscher.


Mainz Resilience Project

The "Mainz Resilience Project" (MARP) is conducted by a consortium of researchers in the departments of Neuroimaging (NIC), Psychiatry and Psychotherapy, Microscopic Anatomy and Neurobiology, and Neurology. MARP aims to build a cohort of healthy young volunteers in Mainz and Mainz-Bingen who are in the critical transition phase between adolescence/school life and professional life, which is associated in many with the onset of new mental health problems. We will accompany these individuals over several years and assess their mental health status and the life stressors they encounter. We are interested in whether certain individual characteristics that our subjects show at the time of their inclusion in the study predict successful coping and resilience. These assessments will be performed using neuroimaging and behavioral examination. Ultimately, we hope to identify brain properties and mental faculties that are crucial protective mechanisms. Our results should provide a sound basis for the development of new prevention strategies. MARP is supported by the foundation “RLP für Innovation“ (Rheinland-Pfalz Ministry of Education) and the Focus Program Translational Neuroscience Mainz (FTN) and operates in close collaboration with the "Gutenberg Brain Study".

Further information about MARP can be found here.

MARP is led by Prof. Raffael Kalisch, Neuroimaging Center Mainz (NIC)