Clinical Investigation Center

Head: Univ.-Prof. Dr. Oliver Tüscher





Tanja Darwiesh, study psychologist
Philipp Horstmann, assistant physician
Karolina Kurth, PhD student
Lara May, PhD student
Dr. Sandra Paryjas, scientist, CIC coordination
Danuta Weichert, study coordination 

Platform overview:
The Clinical Investigation Center (CIC) has a pivotal role within the DRZ, namely to longitudinally determine primary mental outcome measures, i.e., to assess and quantify resilience and is therefore the central organizational and recruitment backbone for human studies at the DRZ. This will be accomplished through the Gutenberg Brain Study (GBS) and its affiliated studies. The CIC will recruit and characterize all individuals who subsequently enter projects being pursued by the DRZ. Working in close collaboration with the NIC, as exemplified by the Mainz Resilience Project (MARP), it aims to identify key neural mechanisms that predict resilient outcomes and to probe the causal effect of these mechanisms on resilience via dedicated training interventions. Since resilience factors against everyday stressors have not systematically been defined, the CIC will initiate a register-based longitudinal study which is rooted in the GBS. A third function of the CIC within the DRZ is to carry out intervention studies, including psychological training programs, pharmacological trials or neurotechnical intervention (e.g., neurofeedback, transcranial stimulation). Thus, the CIC will act as the central executive platform of the DRZ, facilitating the translation of research outcomes from various research areas to human studies. The CIC will conduct these longitudinal studies using cutting-edge ecological momentary assessment and intervention (EMA/EMI) technology.

External collaboration partners:

  • Univ.-Prof. Dr. Ines Germeys, Department of Neurosciences, Leuven, Belgium
  • Univ.-Prof. Dr. Hans Grabe, Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
  • Univ.-Prof. Dr. Martin Lotze, Baltic Neuroimaging Center, University Greifswald, Greifswald, Germany
  • Univ.-Prof. Dr. Henrik Walter, Department of Psychiatry and Psychotherapy, Humboldt University Berlin, Berlin, Germany


  • Ministry of Science of Rheinland Palatinate, Germany

Key Publications:

  • Kalisch R, Müller MB, Tüscher O (2015) From descriptive to mechanistic research in the field of resilience: a conceptual and practical framework for neurobiological and translational studies. Behav Brain Sci 38:e92.
  • Kalisch R, Müller MB, Tüscher O (2015) Advancing empirical resilience research. Behav Brain Sci. 38:e128.
  • Vogt J, Yang JW, Mobascher A, Cheng J, Li Y, Liu X, Baumgart J, Thalman C, Kirischuk S, Unichenko P, Horta G, Radyushkin K, Stroh A, Richers S, Sahragard N, Distler U, Tenzer S, Qiao L, Lieb K, Tüscher O, Binder H, Ferreiros N, Tegeder I, Morris AJ, Gropa S, Nürnberg P, Toliat MR, Winterer G, Luhmann HJ, Huai J, Nitsch R (2016) Molecular cause and functional impact of altered synaptic lipid signaling due to a prg-1 gene SNP. EMBO Mol Med 8(1):25-38.
  • Robbins M, Kubiak T (2014) Ecological Momentary Assessment in behavioural medicine research and practice. In D. Mostofsky (Ed.). Handbook of Behavioral Medicine (pp. 429-446). New York: Wiley-Blackwell.
  • Siewert K, Kubiak T, Jonas C, Weber H (2011) Trait anger moderates the impact of anger-associated rumination on social well-being. Personality and Individual Differences 51(6):769–774.