AG Stroh

Head: Jun.-Prof. Dr. Albrecht Stroh
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Staff:
Dr. Felipe Aedo-Jury, postdoc
Hendrik Backhaus, PhD student
Miriam Schwalm, postdoc

Research overview:
The research group Stroh aims at causally unravelling the neuronal underpinnings of resilient behavior in rodent models of resilience. We focus on primary cortical areas, as in our view, resilient behavior needs to affect already the basic computation of sensory afferences in the cortex. We investigate both local representation of sensory inputs in cortical microcircuits, as well as cortico-cortical integration and interpretation, in behaving rodents. This experimental setting will allow for establishing a causality between spatio-temporal patterns of microcircuit activity and resilient versus susceptible behavior, with a focus on slow oscillations.

Current research projects:

  • Patterns of cortical microcircuit activity of resilient behavior alongside dircrimination learning
  • Representation of a resilient phenotype in resting state networks
  • Causal relation between the initiation and propagation of slow oscillations and resilience

External collaboration partners:

  • Prof. Dr. Rainer Heintzmann, Leibniz Institute of Photonic Technology, Reg. Assoc., Jena, Germany
  • Prof. Dr. Cornelius Faber, Department of Clinical Radiology, University Hospital of Münster, Münster, Germany
  • Prof. William Moody, Department of Biology, University of Washington, Seattle, USA

Funding:

  • German Research Foundation
  • German Ministry of Education and Research
  • Boehringer Ingelheim Foundation

Key publications:

  • Schmid F, Wachsmuth L, Schwalm M, Prouvot P-H, Jubal E R, Fois C, Pramanik G, Zimmer C, Faber C, Stroh A (2016) Assessing sensory versus optogenetic network activation by combining (o)fMRI with optical Ca2+ recordings. Journal of Cerebral Blood Flow & Metabolism 36(11):1885-1900.
  • Cheng J, Sahani S, Hausrat T, Yang J-W, Ji H, Schmarowski N, Endle H, Liu X, Li Y, Böttche R, Radyushkin K, Maric H-M, Hoerder-Suabedissen A, Molnár Z, Prouvot P-H, Trimbuch T, Ninnemann O, Huai J, Fan W, Visentin B, Sabbadini R, Strømgaard K, Stroh A, Luhmann H, Kneussel M, Nitsch R, Vogt J (2016) Precise somatotopic thalamo-cortical axon guidance depends on LPA-mediated PRG-2/Radixin signaling. Neuron 92(1):126-142.
  • Vogt J, Yang JW, Mobascher A, Cheng J, Li Y, Liu X, Baumgart J, Thalman C, Kirischuk S, Unichenko P, Horta G, Radyushkin K, Stroh A, Richers S, Sahragard N, Distler U, Tenzer S, Qiao L, Lieb K, Tüscher O, Binder H, Ferreiros N, Tegeder I, Morris AJ, Gropa S, Nürnberg P, Toliat MR, Winterer G, Luhmann HJ, Huai J, Nitsch R (2016) Molecular cause and functional impact of altered synaptic lipid signaling due to a prg-1 gene SNP. EMBO Mol Med 8(1):25-38.
  • Adelsberger H, Grienberger C, Stroh A, Konnerth A (2014) In Vivo Calcium Recordings and Channelrhodopsin-2 Activation through an Optical Fiber. Cold Spring Harb Protoc 2014(10).
  • Stroh A, Adelsberger H, Groh A, Rühlmann C, Fischer S, Schierloh A, Deisseroth K, Konnerth A. (2013) Making waves: initiation and propagation of corticothalamic Ca2+ waves in vivo. Neuron 77: 1136-1150.