RG Schweiger

Head: Univ.-Prof. Dr. Susann Schweiger
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Staff:
Tamer Butto, PhD student
Stephan Käseberg, PhD student
Dr. Matthias Linke, scientist
Dr. Eva Weiss, scientist
Marlon Wendelmuth, PhD student
Michael Willam, PhD student
Dr. Jennifer Winter, scientist, head of the molecular genetics laboratory

Research overview:
We are looking at the molecular mechanisms that establish in the brain after chronic stress and that result in resilient behaviour. These mechanisms include epigenetic imprints, expression of non-coding RNAs and changes in the transcriptional and translational program of the cell. We focus on chronic social defeat stress on one hand and on different kinds of early life stress on the other and are also interested in the elucidation of putative inheritance of resilient behaviour from one generation to the other. We are using mouse models including the Ribotag and the SUN-GFP mouse that allow cell-specific sorting of affected cells and combine these with single cell RNA sequencing, Bi-sulfite sequencing, ATAC sequencing and mass spectrometry. Epigenetic modulators and mTOR kinase inhibitors are used to modulate resilient behaviour. Furthermore, in human, cortical organoids we are looking at changes in X-inactivation in the developing female brain as a potential mechanism underlying gender specific behaviour.

Current research projects:

  • Epigenetic modulation of early life stress
  • Epigenetic modulation of chronic social defeat stress
  • Heritability of resilient behavior
  • Modulation of resilient behavior through epigenetic modulation and mTOR inhibitors
  • Protein translation after chronic defeat stress
  • X-inactivation in the female brain as a potential modulator of behaviour

External collaboration partners:

  • Prof. Dr. Jochen Roeper, Institute for Neurophysiology, Goethe University Frankfurt, Germany
  • Prof. Dr. Rainer Schneider, Institute for Biochemistry, University Innsbruck, Austria
  • Dr. Vera Kalscheuer, Max Planck Institute for Molecular Genetics, Berlin, Germany
  • Prof. Dr. Benedikt Berninger, Centre for Developmental Neurobiology, King's College London, United Kingdom

Funding:

  • German Research Foundation
  • Boehringer Ingelheim Foundation

Key publications:

  • Deciphering Developmental Disorders Study (2017) Prevalence and architecture of de novo mutations in developmental disorders. Nature 542(7642):433-438.
  • Schweiger S, Dorn S, Fuchs M, Köhler A, Matthes F, Müller EC, Wanker E, Schneider R, Krauß S (2014) The E3-ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu. J Biol Chem 289(46):31805-17. doi: 10.1074/jbc.M113.541219.
  • Krauß S, Griesche N, Jastrzebska E, Chen C, Rutschow D, Achmüller C, Dorn S, Boesch SM, Lalowski M, Wanker E, Schneider R, Schweiger S (2013) Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex. Nature communications 4:1511 doi: 10.1038/ncomms2514.
  • Liu E, Knutzen CA, Krauss S, Schweiger S, Chiang GG (2011) Control of mTORC1 signaling by the Opitz Syndrome protein, MID1. Proc Natl Acad Sci USA 108: 8680-868.
  • Kickstein E, Krauß S, Thornhill P, Rutschow D, Zeller R, Sharkey J, Williamson R, Fuchs M, Köhler A, Glossmann H, Schneider R, Sutherland C, Schweiger S (2010) The Biguanide Metformin acts on tau phosphorylation via mTOR/PP2A signaling. Proc Natl Acad Sci USA 107: 21830-21835.