RG Groppa

Head: Univ.-Prof. Dr. Sergiu Groppa




Manuel Bange, PhD student
Venkata Chaitanya Chirumamilla, PhD student
Gabriel Gonzalez-Escamilla, PhD, postdoc
Prof. Dr. Muthuraman Muthuraman, scientist

Research overview:
Our research group examines the regulation of cortical excitability and the connectivity of the neural networks during resilience related mechanisms, fear and stress processing. In addition to multimodal neurostimulation (transcranial magnetic stimulation (TMS), transcranial direct or current stimulation (tDCS, tACS)), we also apply neurophysiological and imaging techniques such as electroencephalography (EEG) and magnetic resonance imaging (MRI) to gain insight into network dynamics. Non-invasive interventions are developed and applied to explore the spatial-temporal patterns of cerebral responses. We use methods of signal processing such as time-frequency analysis, coherence analysis, source analysis and analysis of the effective connectivity in conjunction with advanced methods of network analysis.

Current research projects:

  • Dynamic network characteristics during fear conditioning and fear processing
  • Cortico-cortical and cortico-subcortical connectivity and stress paradigms
  • Translational networks for resilience mechanisms


  • German Research Foundation
  • Boehringer Ingelheim Foundation

Key publications:

  • Chirumamilla VC, Koirala N, Groppa S (2017) Combining transcranial magnetic stimulation and subdural electrodes for pain modulation. Clin Neurophysiol 128:1041-2.
  • Groppa S (2016) Multifocal TMS for temporo-spatial description of cortico-cortical connectivity patterns. Clin Neurophysiol 127:1005-6.
  • Groppa S, Muthuraman M, Otto B, Deuschl G, Siebner HR, Raethjen J (2013) Subcortical substrates of TMS induced modulation of the cortico-cortical connectivity. Brain Stimul 6:138-46.
  • Groppa S, Oliviero A, Eisen A, Quartarone A, Cohen LG, Mall V, Kaelin-Lang A, Mima T, Rossi S, Thickbroom GW, Rossini PM, Ziemann U, Valls-Solé J, Siebner HR (2012) A practical guide to diagnostic transcranial magnetic stimulation: Report of an IFCN committee. Clin Neurophysiol 123:858-82.
  • Groppa S, Schlaak BH, Münchau A, Werner-Petroll N, Dünnweber J, Bäumer T, van Nuenen BF, Siebner HR (2012) The human dorsal premotor cortex facilitates the excitability of ipsilateral primary motor cortex via a short latency cortico-cortical route. Hum Brain Mapp 33:419-30.